Article: Dietary Regimens Modify Early Onset of Obesity in Mice Haploinsufficient for Rai1

A new article detailing the effect of RAI1 and obesity in mice.

Previous studies have shown that heterozygous knockout of Rai1 results in an obese phenotype in mice and that Smith-Magenis syndrome mouse models have a significantly reduced fecundity and an altered transmission pattern of the mutant Rai1 allele, complicating large, extended studies in these models. In this study, we show that breeding C57Bl/6J Rai1+/2 mice with FVB/NJ to create F1 Rai1+/2 offspring in a mixed genetic background ameliorates both fecundity and Rai1 allele transmission phenotypes.

Read the article:  Alaimo_et_al_2014