Researchers wanted to better understand how the body controls RAI1 protein levels inside cells. They discovered that another protein, called... Read More
In this study, scientists used stem-cell technology to create laboratory models of human brain development from individuals with SMS. They... Read More
To extend knowledge of RAI1 function to nonhuman primates, the Huang lab characterized the spatiotemporal distribution and molecular interactions of... Read More
Loss of RAI1 causes Smith-Magenis syndrome (SMS) and as of now, no drugs have been developed to improve neurometabolic phenotypes... Read More
Haploinsufficiency in retinoic acid induced 1 (RAI1) causes Smith-Magenis syndrome (SMS), a severe neurodevelopmental disorder characterized by neurocognitive deficits and... Read More
Supported by SMSRF, Dr. Wei-Hsiang Huang’s team at McGill University studied the function of Rai1, the disease-causing gene of SMS, at different developmental stage.
This comprehensive review article By Dr. Wei-Hsiang Huang summarizes the genetics and clinical features of Autism Spectrum Disorders that are... Read More
Smith-Magenis Syndrome and its Circadian influence on development, behavior, and obesity. June 2015
SMS and Food-Related Behaviors Equivalent to Prader-Willi.
Copy number loss upstream of RAI1 uncovers gene expression regulatory region that may impact Potocki–Lupski syndrome diagnosis- July 2015
